Description

Carbamic acid, N-[(1S)-1-[[[(1S,2S)-2-hydroxy-1-(phenylmethyl)-3-[1-[[4-(2-pyridinyl)phenyl]methyl]hydrazinyl]propyl]amino]carbonyl]-2,2-dimethylpropyl]-, methyl ester is a high-purity, complex organic intermediate of significant interest in advanced pharmaceutical research and development. This compound, identified by CAS No. 765254-57-7, is valued for its specific stereochemistry and functional groups, which make it a critical building block in the synthesis of targeted therapeutic agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors working on novel drug candidates, particularly in areas requiring sophisticated chiral synthesis.

Application

This specialized carbamate derivative serves as a key synthetic intermediate in several high-value applications:

• Pharmaceutical Intermediate: A crucial building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for complex small-molecule drugs.
• Protease Inhibitor Synthesis: Used in the synthetic pathways for developing protease inhibitors, a class of drugs important for treating conditions like hypertension, HIV, and hepatitis C.
• Chiral Synthesis: Its defined stereochemistry makes it valuable for constructing chiral centers in asymmetric synthesis, ensuring the production of enantiomerically pure compounds.
• Peptidomimetic Research: Acts as a scaffold in the design and synthesis of peptidomimetics, which are molecules that mimic peptides but with enhanced stability and bioavailability.
• Chemical Biology Probes: Utilized in the development of specialized probes for studying enzyme mechanisms and protein-protein interactions within biological systems.
• Process Chemistry Development: Serves as a reference standard or a starting material for scaling up and optimizing manufacturing routes for candidate drugs.

Basic Information

Item	Details
Product Name	Carbamic acid, N-[(1S)-1-[[[(1S,2S)-2-hydroxy-1-(phenylmethyl)-3-[1-[[4-(2-pyridinyl)phenyl]methyl]hydrazinyl]propyl]amino]carbonyl]-2,2-dimethylpropyl]-, methyl ester
CAS No.	765254-57-7
Molecular Formula	C31H41N5O4
Molecular Weight	547.69 g/mol
Synonyms	Methyl N-[(2S)-3,3-dimethyl-1-({(2S,3S)-3-hydroxy-1-phenyl-4-[(4-(pyridin-2-yl)benzyl)hydrazinyl]butan-2-yl}carbamoyl)butan-2-yl]carbamate; (2S,3S)-N1-[(2S)-2-[(Methoxycarbonyl)amino]-3,3-dimethylbutanoyl]-3-hydroxy-1-phenyl-4-[(4-(pyridin-2-yl)benzyl)hydrazinyl]butan-2-amine; Boceprevir Intermediate; Boceprevir Related Compound; HCV Protease Inhibitor Intermediate; SCH 503034 Intermediate; Carbamic acid methyl ester derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) are provided, detailing comprehensive specifications. We support development under cGMP guidelines where required, ensuring suitability for use in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.