Description

Methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-dimethylamino-5-[(2S,4S,5R,6S)-4-hydroxy-6-methyl-5-[(2S,6S)-6-methyl-5-oxo-oxan-2-yl]oxy-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-2,5,7-trihydroxy-2-methyl-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate is a complex, stereochemically defined chemical intermediate of significant interest in advanced pharmaceutical synthesis. Its intricate molecular architecture, featuring multiple chiral centers and functional groups, makes it a critical building block for the development of novel therapeutic agents. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of complex natural product derivatives and targeted small molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly in the anthracycline and tetracycline analog families.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and the exploration of new chemical entities with potential biological activity.
• Antibiotic Research: Acts as a sophisticated scaffold for the development of next-generation antibiotics, leveraging its core tetracyclic structure.
• Anticancer Agent Synthesis: Employed in the research and production of novel chemotherapeutic compounds due to its structural similarity to known DNA-intercalating agents.
• Process Chemistry: Utilized in the development and optimization of scalable synthetic routes for high-value, stereochemically complex targets.
• Bioconjugation Chemistry: The functional groups present allow for potential use in creating targeted drug conjugates or prodrugs.

Basic Information

Product Name	Methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-dimethylamino-5-[(2S,4S,5R,6S)-4-hydroxy-6-methyl-5-[(2S,6S)-6-methyl-5-oxo-oxan-2-yl]oxy-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-2,5,7-trihydroxy-2-methyl-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate
CAS No.	78173-92-9
Molecular Formula	C₄₃H₅₅NO₁₇
Molecular Weight	881.90 g/mol
Synonyms	Methyl 4-O-(4-Dimethylamino-5-O-[4-hydroxy-6-methyl-5-O-(6-methyl-5-oxo-2-tetrahydropyranyl)-2-tetrahydropyranyl]-6-methyl-2-tetrahydropyranyl)-2,5,7-trihydroxy-2-methyl-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate; Daunorubicin derivative intermediate; 4'-O-Methyl-13-deoxocarminomycin methyl ester; Aclacinomycin A aglycone derivative; (1R,2R,4S)-1-(Methoxycarbonyl)-2,5,7-trihydroxy-2-methyl-6,11-dioxo-4-[(2S,4S,5S,6S)-4-(dimethylamino)-5-[(2S,4S,5R,6S)-4-hydroxy-6-methyl-5-[(2S,6S)-6-methyl-5-oxo-2-tetrahydropyranyl]oxy-2-tetrahydropyranyl]oxy-6-methyl-2-tetrahydropyranyl]oxy-3,4-dihydro-1H-tetracene
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to stringent quality protocols suitable for pharmaceutical research and development. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing key parameters such as assay (HPLC), chiral purity, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange-red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.