Description

(1aR)-9β,9aα-Bis(acetyloxy)-3-(acetyloxy)methyl-2α-chloro-1,1aα,1bβ,2,3,4,4a,7aα,7bα,8,9,9a-dodecahydro-3α,4aβ,7bα-trihydroxy-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one is a complex, high-purity diterpenoid derivative with a unique cyclopropane-fused azulene core structure. This compound is a critical advanced pharmaceutical intermediate or reference standard, valued for its precise stereochemistry and functional group array which enables sophisticated synthetic pathways. It is primarily required by research institutions and pharmaceutical development teams working on novel therapeutic agents, particularly in oncology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of novel drug candidates, especially complex natural product analogs.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical R&D and manufacturing.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new bioactive molecules targeting specific enzymes or receptors.
• Process Chemistry Development: Acts as a benchmark compound for optimizing synthetic routes, scaling up production, and ensuring batch-to-batch consistency.
• Academic Research: Utilized in universities and research institutes for studies in organic synthesis, chemical biology, and the exploration of diterpenoid chemistry.

Basic Information

Item	Details
Product Name	(1aR)-9β,9aα-Bis(acetyloxy)-3-(acetyloxy)methyl-2α-chloro-1,1aα,1bβ,2,3,4,4a,7aα,7bα,8,9,9a-dodecahydro-3α,4aβ,7bα-trihydroxy-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
CAS No.	77573-33-2
Molecular Formula	C28H37ClO10
Molecular Weight	569.04 g/mol
Synonyms	2α-Chloro-3α,4aβ,7bα-trihydroxy-1,1,6,8α-tetramethyl-1,1aα,1bβ,2,3,4,4a,7aα,7bα,8,9,9a-dodecahydro-9β,9aα-bis(acetyloxy)-3-(acetyloxy)methyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one; CAS 77573-33-2; A complex diterpenoid azulenone derivative; Chlorinated polyacetylated azulenone; Advanced pharmaceutical intermediate 77573-33-2.
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and verified under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.