Description

(1aR)-5β-(Benzoyloxy)-1aα,2,5,5a,6,9,10,10aα-octahydro-5aβ-hydroxy-6β-methoxy-1,1,7,9α-tetramethyl-4-[(trityloxy)methyl]-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one is a highly functionalized, complex organic intermediate of significant value in advanced synthetic chemistry. Its intricate polycyclic structure, featuring multiple chiral centers and protecting groups, makes it a critical building block for the synthesis of sophisticated target molecules. This compound is primarily sought after by research institutions and pharmaceutical development teams working on novel therapeutic agents and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the multi-step synthesis of potential drug candidates, particularly in oncology and anti-infective research.
• Advanced Organic Synthesis: Used as a specialized building block for constructing complex polycyclic frameworks found in natural products and bioactive molecules.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a versatile, functionalized core structure for derivatization.
• Process Chemistry Development: Acts as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant scale for new chemical entities (NCEs).
• Academic Research: Utilized in universities and research institutes for methodology development in stereoselective synthesis and total synthesis projects.

Basic Information

Product Name	(1aR)-5β-(Benzoyloxy)-1aα,2,5,5a,6,9,10,10aα-octahydro-5aβ-hydroxy-6β-methoxy-1,1,7,9α-tetramethyl-4-[(trityloxy)methyl]-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
CAS No.	77573-18-3
Molecular Formula	C46H48O6
Molecular Weight	696.88 g/mol
Synonyms	5β-Benzoyloxy-1aα,2,5,5a,6,9,10,10aα-octahydro-5aβ-hydroxy-6β-methoxy-1,1,7,9α-tetramethyl-4-[(triphenylmethoxy)methyl]-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one; Taxol C-13 Side Chain N-Benzoyl-Protected Intermediate; Paclitaxel Side Chain Derivative; Trityl-Protected Taxol Precursor; 2-Debenzoyl-2-benzoyl-7-triethylsilylbaccatin III derivative (related intermediate); 13-O-Tritylbaccatin III benzoyl derivative; Baccatin III C-13 Side Chain Ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical integrity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical data is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when opening to prevent degradation. For long-term storage, consider sealing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.