Description

4-O-(2-Amino-6-methylamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-6-O-[4-C-methyl-3-(methylamino)-3-deoxy-β-L-arabino-pentopyranosyl]-N'-methyl-2-deoxy-D-streptamine is a complex aminoglycoside derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and analysis of novel antibiotic agents. It is primarily utilized by research institutions and pharmaceutical companies focused on developing next-generation therapeutics to combat resistant bacterial strains. The precise stereochemistry and functional groups of this molecule make it a valuable building block for medicinal chemistry.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for quality control and analytical method development in antibiotic production.
• Medicinal Chemistry Intermediate: Serves as a key synthetic precursor for the research and development of novel semi-synthetic aminoglycoside antibiotics.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) and mechanisms of action of aminoglycoside-class drugs.
• Antibiotic Resistance Studies: Utilized as a tool compound in research aimed at understanding and overcoming bacterial resistance mechanisms.
• Process Development: Acts as an intermediate in the scale-up and optimization of synthetic routes for complex antibiotic molecules.

Basic Information

Item	Details
Product Name	4-O-(2-Amino-6-methylamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-6-O-[4-C-methyl-3-(methylamino)-3-deoxy-β-L-arabino-pentopyranosyl]-N'-methyl-2-deoxy-D-streptamine
CAS No.	74758-67-1
Molecular Formula	C26H50N6O11
Molecular Weight	622.71 g/mol
Synonyms	6'-N-Methylsisomicin; Antibiotic G 52; Antibiotic G-52; G 52 Antibiotic; G-52; Sisomicin, 6'-N-methyl-; 6'-N-Methylsisomicin; Demethylsisomicin (ambiguous); (2S,3R,4S,5S,6R)-4-[[(1S,2S,3R,4S,6R)-4,6-Diamino-3-[[(2R,3R,4R,5R)-3,5-diamino-2,4,6-trihydroxycyclohexyl]methylamino]-2-hydroxycyclohexyl]oxy]-2-methyl-6-(methylamino)tetrahydro-2H-pyran-3,5-diol
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment. We support compliance with cGMP guidelines for active pharmaceutical ingredients (APIs) and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0% w/w
Residual Solvents (GC)	Complies with ICH guidelines
Assay (on dried basis)	95.0% - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.