Description

(diethyl phosphoric) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic anhydride is a high-purity, complex steroid derivative designed for advanced pharmaceutical research and synthesis. This compound is a critical chemical intermediate for developing novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of fluorinated corticosteroids and other specialized steroid-based molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent fluorinated corticosteroid APIs (Active Pharmaceutical Ingredients).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new steroid-based drug candidates.
• Process Chemistry: Serves as a critical intermediate in scale-up and process optimization for the commercial manufacturing of steroid drugs.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating steroid hormone receptor interactions and metabolic pathways.

Basic Information

Product Name	(diethyl phosphoric) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic anhydride
CAS No.	73205-12-6
Molecular Formula	C₂₈H₃₈F₂O₈P
Molecular Weight	580.57 g/mol
Synonyms	6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate 21-(diethyl phosphate); Fluticasone Propionate EP Impurity G (Diethyl Phosphate); Fluticasone Propionate Related Compound G; Fluticasone Dipropionate Phosphate Ester; 6α,9α-Difluoro-11β-hydroxy-16α-methyl-17α-(1-oxopropoxy)-3-oxo-androsta-1,4-diene-17β-carboxylic acid, diethyl phosphate anhydride; SPLX; Diethyl phosphoric ester of Fluticasone propionate.
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure high chemical purity and consistency, suitable for demanding pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality systems are designed to support compliance with cGMP and relevant pharmacopeial standards (e.g., USP, EP) for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.