Description

5-[(3aR,4R,5R,6aS)-5-(Tetrahydro-2H-pyran-2-yloxy)-4-[(1E,3S,5S)-5-methyl-3-(tetrahydro-2H-pyran-2-yloxy)-1-nonenyl]hexahydro-2H-cyclopenta[b]furan-2-yl]-5-iodovaleric acid methyl ester is a sophisticated, high-purity synthetic intermediate characterized by its complex stereochemistry and functional groups. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of prostaglandin and prostanoid analogs. It is essential for medicinal chemists and process development teams in the pharmaceutical and fine chemical industries requiring advanced building blocks for targeted drug discovery programs.

Application

• Key Intermediate in Prostaglandin Synthesis: Serves as a critical precursor in the multi-step synthesis of prostaglandin derivatives and related bioactive molecules.
• Pharmaceutical R&D: Used in medicinal chemistry for the discovery and development of new therapeutic agents targeting inflammation, cardiovascular function, and other physiological pathways.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized as a tool compound in pharmacological studies to investigate prostanoid receptor interactions and signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized fine chemicals and advanced intermediates.

Basic Information

Product Name	5-[(3aR,4R,5R,6aS)-5-(Tetrahydro-2H-pyran-2-yloxy)-4-[(1E,3S,5S)-5-methyl-3-(tetrahydro-2H-pyran-2-yloxy)-1-nonenyl]hexahydro-2H-cyclopenta[b]furan-2-yl]-5-iodovaleric acid methyl ester
CAS No.	70667-58-2
Molecular Formula	C30H49IO7
Molecular Weight	648.62 g/mol
Synonyms	Methyl 5-[(3aR,4R,5R,6aS)-5-(Tetrahydro-2H-pyran-2-yloxy)-4-[(1E,3S,5S)-5-methyl-3-(tetrahydro-2H-pyran-2-yloxy)-1-nonenyl]hexahydro-2H-cyclopenta[b]furan-2-yl]-5-iodopentanoate; 5-Iodovaleric Acid Methyl Ester Prostaglandin Intermediate; THP-Protected Prostaglandin Intermediate; 70667-58-2; Prostanoid Synthesis Intermediate; Iodopentanoate Prostaglandin Precursor
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Purity (GC)	≥ 95.0%
Diastereomeric Purity	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.