Description

(1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester is a complex, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly in the fields of oncology and antiviral drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of complex, stereochemically defined active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral precursor in the multi-step synthesis of novel, high-value active pharmaceutical ingredients (APIs).
• Anticancer Drug Research: Used as a sophisticated scaffold in the discovery and development of targeted cancer therapies.
• Antiviral Agent Development: Serves as a core structural component in the research of new antiviral compounds.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing for new chemical entities (NCEs).
• Chemical Biology & Proteomics: Utilized as a specialized tool compound or probe in mechanistic studies and target identification.
• Academic Research: Used in university and institutional laboratories for advanced synthetic methodology and medicinal chemistry projects.

Basic Information

Item	Detail
Product Name	(1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester
CAS No.	697235-38-4
Molecular Formula	C38H42O14
Molecular Weight	722.73 g/mol
Synonyms	Methyl (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxylate; CAS 697235-38-4; Cyclopenta[b]benzofuran derivative; Complex glycosylated benzofuran intermediate; Advanced pharmaceutical building block.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity essential for sensitive pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support development under cGMP guidelines as required for preclinical and clinical stage materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.