Description

(3'R,6S,9R)-5,6,7,8,9,10-Hexahydro-5'-(2,2,2-trifluoroethyl)-2-[(1E)-3-[4-(trifluoromethyl)-1-piperidinyl]-1-propen-1-yl]spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazolidine] 1',1'-dioxide is a high-purity, complex organic compound featuring a unique spirocyclic structure with trifluoromethyl and trifluoroethyl functional groups. This compound is of significant interest for advanced pharmaceutical research and development, particularly as a key intermediate or active pharmaceutical ingredient (API) precursor in the synthesis of novel therapeutics. It is primarily targeted at R&D laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in developing new chemical entities for challenging disease targets.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potential drug candidates, especially in central nervous system (CNS) or oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of its complex spiro architecture and fluorine substituents on biological activity.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for the production of target molecules in preclinical and clinical development phases.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Biochemical Probe Development: Potential use in creating tool compounds for investigating specific biological pathways and protein targets.

Basic Information

Item	Details
Product Name	(3'R,6S,9R)-5,6,7,8,9,10-Hexahydro-5'-(2,2,2-trifluoroethyl)-2-[(1E)-3-[4-(trifluoromethyl)-1-piperidinyl]-1-propen-1-yl]spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazolidine] 1',1'-dioxide
CAS No.	623165-93-5
Molecular Formula	C29H33F6N3O2S
Molecular Weight	601.65 g/mol
Synonyms	BMS-820836; BMS 820836; BMS820836; (3'R,6S,9R)-5,6,7,8,9,10-Hexahydro-5'-(2,2,2-trifluoroethyl)-2-[(1E)-3-[4-(trifluoromethyl)-1-piperidinyl]-1-propen-1-yl]spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazolidine] 1',1'-dioxide; Spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazolidine] derivative
EINECS	Contact for details

Quality Control

Our (3'R,6S,9R)-5,6,7,8,9,10-Hexahydro-5'-(2,2,2-trifluoroethyl)-2-[(1E)-3-[4-(trifluoromethyl)-1-piperidinyl]-1-propen-1-yl]spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazolidine] 1',1'-dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, NMR, and MS analyses. We support cGMP compliance for advanced R&D and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the certificate of analysis. This compound is moisture-sensitive (hygroscopic); store under an inert atmosphere such as nitrogen or argon in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.