Description

1-Piperidinecarboxylic acid, 3-[7-[2-(cyclopropylMethoxy)-6-[(4-Methoxyphenyl)Methoxy]phenyl]-1,4-dihydro-2-oxo-2H-pyrido[2,3-d][1,3]oxazin-5-yl]-, 1,1-diMethylethyl ester, (3R)- is a sophisticated chiral piperidine derivative and a key advanced pharmaceutical intermediate. Its complex molecular architecture, featuring fused pyrido-oxazinone and substituted phenyl rings, makes it a critical building block for the synthesis of novel therapeutic agents. This high-purity intermediate is essential for research and development organizations and pharmaceutical manufacturers targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or oncology targets.
• Medicinal Chemistry Research: Used as a scaffold or precursor in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a reference standard and a starting material for scaling up and optimizing synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Protease Inhibitor Synthesis: The structural motifs suggest potential application in the development of enzyme inhibitors, such as protease or kinase inhibitors.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.

Basic Information

Item	Details
Product Name	1-Piperidinecarboxylic acid, 3-[7-[2-(cyclopropylMethoxy)-6-[(4-Methoxyphenyl)Methoxy]phenyl]-1,4-dihydro-2-oxo-2H-pyrido[2,3-d][1,3]oxazin-5-yl]-, 1,1-diMethylethyl ester, (3R)-
CAS No.	600734-05-2
Molecular Formula	C35H39N3O7
Molecular Weight	613.70 g/mol
Synonyms	(3R)-tert-Butyl 3-(7-(2-(cyclopropylmethoxy)-6-((4-methoxybenzyl)oxy)phenyl)-1,4-dihydro-2-oxo-2H-pyrido[2,3-d][1,3]oxazin-5-yl)piperidine-1-carboxylate; (R)-tert-Butyl 3-(7-(2-(cyclopropylmethoxy)-6-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-5-yl)piperidine-1-carboxylate; tert-Butyl (3R)-3-[7-[2-(cyclopropylmethoxy)-6-[(4-methoxyphenyl)methoxy]phenyl]-1,4-dihydro-2-oxo-2H-pyrido[2,3-d][1,3]oxazin-5-yl]piperidine-1-carboxylate; BOC-protected pyridooxazinone piperidine intermediate; CAS 600734-05-2
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and chiral integrity. Standard testing includes chiral HPLC for enantiomeric excess, NMR, and mass spectrometry for structural confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, and residual solvents. We support development with custom specifications aligned with ICH guidelines and current Good Manufacturing Practice (cGMP) principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.