Description

2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16- trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren -17-yl]-2-oxo-ethyl] pyridine-4-carboxylate is a high-purity synthetic steroid derivative with a complex molecular architecture, designed for advanced pharmaceutical research and development. This compound is valued for its role as a critical pharmaceutical intermediate in the synthesis of potent glucocorticoid receptor modulators and other therapeutic agents. It is primarily sought by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of novel anti-inflammatory and immunosuppressive drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of advanced corticosteroid drugs and glucocorticoid receptor agonists.
• Anti-inflammatory Drug Research: Used in R&D for developing new therapeutic agents targeting inflammatory pathways with enhanced potency and selectivity.
• Immunosuppressant Development: Serves as a precursor in the creation of compounds for managing autoimmune disorders and preventing organ transplant rejection.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Metabolic Studies: Utilized in preclinical research to investigate the metabolism, pharmacokinetics, and structure-activity relationships (SAR) of steroid-based therapeutics.
• Process Chemistry: Integral to scaling up and optimizing synthetic routes for the commercial production of steroid APIs (Active Pharmaceutical Ingredients).

Basic Information

Product Name	2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16- trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren -17-yl]-2-oxo-ethyl] pyridine-4-carboxylate
CAS No.	68402-70-0
Molecular Formula	C28H32FNO6
Molecular Weight	497.56 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(4-pyridinecarboxylate); Fludrocortisone 21-isonicotinate; 21-Isonicotinoylfludrocortisone; 21-(Isonicotinoyloxy)-9-fluoro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-(4-pyridinecarboxylate); Fludrocortisone 21-(4-pyridylcarboxylate); (11β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-(4-pyridinecarboxylate)
EINECS	Contact for details

Quality Control

Our 2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16- trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren -17-yl]-2-oxo-ethyl] pyridine-4-carboxylate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch. Our quality protocols are designed to support compliance with cGMP (Current Good Manufacturing Practice) guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.