Description

[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-17-(2-chloroacetyl)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate is a high-purity, synthetically derived steroid derivative with a complex, multi-chiral structure. This compound is a critical advanced pharmaceutical intermediate (API) for the research and development of potent glucocorticoid receptor modulators. It is essential for pharmaceutical manufacturers and research institutions focused on developing novel anti-inflammatory, immunosuppressive, and dermatological therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel, high-potency corticosteroid APIs.
• Drug Discovery & Development: Used in medicinal chemistry research for structure-activity relationship (SAR) studies targeting glucocorticoid receptors.
• Anti-inflammatory Agent Synthesis: Precursor for developing next-generation topical and systemic anti-inflammatory drugs.
• Immunosuppressant Research: Serves as a core structure for creating compounds that modulate immune response.
• Dermatological Preparations: Intermediate for active ingredients in creams and ointments for treating psoriasis, eczema, and other skin conditions.
• Biochemical Research: A tool compound for studying steroid hormone receptor mechanisms and signaling pathways in vitro.

Basic Information

Product Name	[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-17-(2-chloroacetyl)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
CAS No.	66852-61-7
Molecular Formula	C25H29Cl2FO5
Molecular Weight	511.40 g/mol
Synonyms	9-Chloro-6-fluoro-11β,17-dihydroxy-16β-methyl-3-oxoandrosta-1,4-diene-17α-propionate 17-(2-chloroacetate); 6α-Fluoro-9α-chloro-11β-hydroxy-16α-methyl-17α-(2-chloroacetyl)-1,4-pregnadiene-3,20-dione 17-propionate; Clobetasol propionate 17-(2-chloroacetate) intermediate; Clobetasol propionate key synthon; (6α,11β,16β)-9-Chloro-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-(2-chloroacetate) 21-propionate derivative; Steroid C-17 chloroacetyl ester intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.