Description

(E)-2-Methyl-2-butenoic acid (3aS)-3b,4aβ,5,5aα,6,7,8aβ,8bα-octahydro-1-(hydroxymethyl)-3bβ-methyl-6-methylene-5,7-dioxooxireno[7,8]azuleno[4,5-b]furan-3aα(3H)-yl ester is a high-purity, complex organic ester derivative with a unique fused-ring structure. This compound is valued as a critical advanced intermediate in the synthesis of complex natural products and novel pharmaceutical candidates. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of novel active pharmaceutical ingredients (APIs), particularly for complex molecular targets.
• Organic Synthesis Research: Used in academic and industrial laboratories to study complex cyclization reactions and the construction of polycyclic frameworks.
• Natural Product Synthesis: Serves as a sophisticated precursor in the total or semi-synthesis of complex natural products with potential biological activity.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring high structural precision and purity for advanced applications.
• Chemical Biology Probes: Potential use in the development of molecular probes for studying enzyme mechanisms or biological pathways due to its reactive functional groups.

Basic Information

Product Name	(E)-2-Methyl-2-butenoic acid (3aS)-3b,4aβ,5,5aα,6,7,8aβ,8bα-octahydro-1-(hydroxymethyl)-3bβ-methyl-6-methylene-5,7-dioxooxireno[7,8]azuleno[4,5-b]furan-3aα(3H)-yl ester
CAS No.	65580-16-7
Molecular Formula	C₂₀H₂₄O₇
Molecular Weight	376.40 g/mol
Synonyms	Artemether Impurity 11; (E)-2-Methylcrotonic acid (3aS)-3b,4aβ,5,5aα,6,7,8aβ,8bα-octahydro-1-(hydroxymethyl)-3bβ-methyl-6-methylene-5,7-dioxooxireno[7,8]azuleno[4,5-b]furan-3aα(3H)-yl ester; Tiglic acid artemether derivative; 3aR,3bS,4aS,5R,8aS,8bR,9aS)-8b-(Hydroxymethyl)-4a,8a-dimethyl-3-methylidene-2,5,7-trioxo-3a,3b,4a,5,8a,8b,9,9a-octahydroazuleno[6,5-b]furan-3-yl (E)-2-methylbut-2-enoate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent GMP and ISO 9001 quality management principles. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure structural identity and purity. Comprehensive Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.