Description

Spiro[furan-2(5H),9'-[9H]imidazo[1,2-a]indole]-3',5(2'H)-dione, 4-[2-[(1S)-1-(acetyloxy)-2-methylpropyl]-4-oxo-3(4H)-quinazolinyl]-1',3,4,9'a-tetrahydro-1'-hydroxy-2'-methyl-, (2S,2'S,4R,9'aS)- is a complex, high-purity spirocyclic organic compound with significant synthetic utility. This molecule serves as a critical advanced intermediate in the development of novel pharmaceutical agents, particularly those targeting central nervous system and oncological pathways. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of sophisticated active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially for neurological and cancer therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Process Chemistry Development: Serves as a pivotal intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic & Contract Research: Employed in university and CRO settings for exploratory organic synthesis and methodology development.
• Bioconjugation & Probe Synthesis: Potential use in creating labeled compounds or molecular probes for biological assays and diagnostics.

Basic Information

Product Name	Spiro[furan-2(5H),9'-[9H]imidazo[1,2-a]indole]-3',5(2'H)-dione, 4-[2-[(1S)-1-(acetyloxy)-2-methylpropyl]-4-oxo-3(4H)-quinazolinyl]-1',3,4,9'a-tetrahydro-1'-hydroxy-2'-methyl-, (2S,2'S,4R,9'aS)-
CAS No.	60676-56-4
Molecular Formula	C28H26N4O7
Molecular Weight	530.53 g/mol
Synonyms	4-[2-[(1S)-1-(Acetyloxy)-2-methylpropyl]-4-oxo-3(4H)-quinazolinyl]-1',3,4,9'a-tetrahydro-1'-hydroxy-2'-methyl-spiro[furan-2(5H),9'-[9H]imidazo[1,2-a]indole]-3',5(2'H)-dione, (2S,2'S,4R,9'aS)-; (2S,2'S,4R,9'aS)-4-[2-[(1S)-1-(Acetyloxy)-2-methylpropyl]-4-oxo-3,4-dihydroquinazolin-2-yl]-1',3,4,9'a-tetrahydro-1'-hydroxy-2'-methylspiro[furan-2(5H),9'-[9H]imidazo[1,2-a]indole]-3',5(2'H)-dione; Spirocyclic imidazoindole-quinazolinone derivative; Advanced spirocyclic pharmaceutical intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development and commercial projects with material suitable for use under GMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.