Description

(3R)-4,5-Dihydro-3β-(3-furyl)-7-[[(2S,4S)-4-[(2S)-2,5-dihydro-2-methyl-5-oxofuran-2-yl]-2-hydroxy-5,5-dimethyltetrahydrofuran-2-yl]methyl]-3aβ,7aβ-methanoisobenzofuran-1(3H)-one is a complex, high-purity chiral organic compound characterized by its intricate fused ring system containing multiple stereogenic centers. This compound is of significant value as a key synthetic intermediate or advanced building block in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the multi-step synthesis of novel drug candidates, particularly in oncology, antiviral, or central nervous system (CNS) therapeutic areas.
• Asymmetric Synthesis: Utilized in research to construct complex molecular architectures with defined stereochemistry, leveraging its multiple stereocenters for chiral induction.
• Medicinal Chemistry Research: Employed as a scaffold or precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and route scouting for the commercial manufacturing of target APIs, where its consistent quality is paramount.
• Reference Standard: Supplied as a high-purity analytical standard for method development, quality control, and regulatory submissions.
• Academic & Institutional Research: Applied in synthetic organic chemistry studies focusing on novel ring-forming reactions and stereoselective transformations.

Basic Information

Item	Details
Product Name	(3R)-4,5-Dihydro-3β-(3-furyl)-7-[[(2S,4S)-4-[(2S)-2,5-dihydro-2-methyl-5-oxofuran-2-yl]-2-hydroxy-5,5-dimethyltetrahydrofuran-2-yl]methyl]-3aβ,7aβ-methanoisobenzofuran-1(3H)-one
CAS No.	60675-72-1
Molecular Formula	C27H30O8
Molecular Weight	482.52 g/mol
Synonyms	7-[[(2S,4S)-4-[(2S)-2,5-Dihydro-2-methyl-5-oxo-2-furanyl]-2-hydroxy-5,5-dimethyltetrahydro-2-furanyl]methyl]-3β-(3-furyl)-3aβ,7aβ-methano-4,5-dihydroisobenzofuran-1(3H)-one, (3R)-; 3aβ,7aβ-Methanoisobenzofuran-1(3H)-one, 4,5-dihydro-3β-(3-furyl)-7-[[(2S,4S)-4-[(2S)-2,5-dihydro-2-methyl-5-oxo-2-furanyl]-2-hydroxy-5,5-dimethyltetrahydro-2-furanyl]methyl]-, (3R)-; Complex Furanone Derivative; Chiral Fused Ring Lactone Intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency suitable for demanding pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert atmosphere conditions to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.