Description

O-3-Deoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-D-glucopyranosyl-(1→6)-O-[2,3,6-trideoxy-2,6-bis[[(1,1-dimethylethoxy)carbonyl]amino]-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-N3-[(1,1-dimethylethoxy)carbonyl]-D-streptamine is a sophisticated, high-purity chemical intermediate characterized by its complex glycosidic and protected amine structure. This compound is of critical importance in advanced pharmaceutical research and development, particularly in the synthesis of novel aminoglycoside antibiotics and complex carbohydrate-based therapeutics. It serves as a key building block for medicinal chemists and process development scientists working in antibiotic discovery, glycobiology research, and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel semi-synthetic aminoglycoside antibiotics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new antimicrobial agents with improved efficacy and reduced toxicity.
• Glycoconjugate Synthesis: Serves as a protected glycosyl donor or acceptor for constructing complex oligosaccharide chains in glycopeptide and glycolipid mimetics.
• Process Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.
• Biochemical Tool: Used as a substrate or inhibitor in enzymatic studies related to carbohydrate metabolism and bacterial ribosome function.
• Antibiotic Resistance Research: Investigated for modifying existing antibiotic scaffolds to overcome bacterial resistance mechanisms.

Basic Information

Product Name	O-3-Deoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-D-glucopyranosyl-(1→6)-O-[2,3,6-trideoxy-2,6-bis[[(1,1-dimethylethoxy)carbonyl]amino]-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-N3-[(1,1-dimethylethoxy)carbonyl]-D-streptamine
CAS No.	502610-98-2
Molecular Formula	C36H55F3N4O17
Molecular Weight	872.84 g/mol
Synonyms	Boc-Protected Kanamycin A Derivative; 3'''-Deoxy-3'''-(trifluoroacetamido)-6'-O-[2,3,6-trideoxy-2,6-bis(tert-butoxycarbonylamino)-α-D-ribo-hexopyranosyl]-2'-deoxy-N3-(tert-butoxycarbonyl)kanamycin A; 2-Deoxy-N3-[(tert-butoxycarbonyl)]-O-3-deoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-D-glucopyranosyl-(1→6)-O-[2,3,6-trideoxy-2,6-bis[(tert-butoxycarbonyl)amino]-α-D-ribo-hexopyranosyl-(1→4)]-D-streptamine; Kanamycin A Intermediate, Boc/TFA Protected; tert-Butyl (2R,3S,4R,5R,6R)-5-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2R,3R,4R,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-[[(2R,3S,4R,5R)-4-[(2,2-dimethylpropanoyl)amino]-5-[(2,2-dimethylpropanoyl)amino]-2,3-dihydroxy-6-methyloxan-2-yl]oxy]-4-[(2,2,2-trifluoroacetyl)amino]-2-hydroxyoxane-3-carboxylate
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols suitable for research and pharmaceutical development. Each batch is characterized using advanced analytical techniques to ensure structural integrity and purity. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and mass spectrometry. Our quality system is designed to support regulatory filings and ensure batch-to-batch consistency for critical R&D and scale-up work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.