Description

D-GlutaMic acid, N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxyMethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]aMino]benzoyl]-L-γ-glutaMyl-yl]aMino]benzoyl]-L-γ-glutaMyl- is a high-purity, complex synthetic intermediate with a defined stereochemistry, designed for advanced research and development. This compound is critical for pharmaceutical and biochemical applications where precise molecular structure and high purity are non-negotiable for efficacy and safety. It is primarily utilized by researchers and manufacturers in the life sciences sector, particularly in oncology and targeted therapy development, as a key building block for novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel small-molecule drug candidates, particularly in oncology research.
• Biochemical Research: Used as a specialized reagent in proteomics and enzyme inhibition studies to investigate specific biological pathways.
• Antifolate Agent Development: Acts as a key structural component in the research and development of next-generation antifolate compounds.
• Targeted Therapy Conjugates: Employed in the design and synthesis of antibody-drug conjugates (ADCs) and other targeted delivery systems.
• Chemical Biology Probes: Utilized to create molecular probes for studying cellular processes and target engagement.
• Process Development: Supports scale-up and optimization studies for the commercial manufacturing of advanced active pharmaceutical ingredients (APIs).

Basic Information

Product Name	D-GlutaMic acid, N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxyMethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]aMino]benzoyl]-L-γ-glutaMyl-yl]aMino]benzoyl]-L-γ-glutaMyl-
CAS No.	501332-69-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-[4-[(2-Propyn-1-yl)[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl]-D-glutamic acid; (6S)-N-[4-[[(2-Propyn-1-yl)amino][(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl]-D-glutamic acid; AG2037; AG-2037; Plevitrexed; BGC 9331; BG-9331; Cyclopenta[g]quinazoline-based antifolate.
EINECS	Contact for details

Quality Control

Our D-GlutaMic acid, N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxyMethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]aMino]benzoyl]-L-γ-glutaMyl-yl]aMino]benzoyl]-L-γ-glutaMyl- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements, including those for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.