Description

((4S,5S)-(+)-O-[1-Benzyl-1-(5-methyl-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-phenylethyl]-diphenyl-phosphinite)(1,5-COD)iridium (I) tetrakis(3,5-bis(trifluoromethyl)phenyl)borate is a highly specialized, chiral iridium(I) complex designed for advanced asymmetric catalysis. This compound is valued for its exceptional enantioselectivity and catalytic activity in challenging chemical transformations. It is a critical reagent for research and development chemists in the pharmaceutical and fine chemical industries, particularly for the synthesis of complex, optically active molecules.

Application

• Asymmetric Hydrogenation: A premier catalyst for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral intermediates with high optical purity.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective construction of chiral centers in active pharmaceutical ingredients (APIs) and drug candidates.
• Fine Chemical Manufacturing: Used in the production of high-value specialty chemicals, including fragrances, flavors, and agrochemicals requiring specific stereochemistry.
• Methodology Development: A key tool for academic and industrial research groups developing new catalytic asymmetric reactions and processes.
• Process Chemistry Optimization: Employed in scaling up enantioselective reactions from laboratory to pilot plant scale with maintained selectivity and yield.

Basic Information

Product Name	((4S,5S)-(+)-O-[1-Benzyl-1-(5-methyl-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-phenylethyl]-diphenyl-phosphinite)(1,5-COD)iridium (I) tetrakis(3,5-bis(trifluoromethyl)phenyl)borate
CAS No.	405235-55-4
Molecular Formula	C96H78BF24IrNOP
Molecular Weight	~1870.5 g/mol
Synonyms	Iridium(I) (1,5-cyclooctadiene)((4S,5S)-4-(1-Benzyl-2-phenylethyl)-2-(5-methyl-2-phenyl-4,5-dihydrooxazol-4-yl))diphenylphosphinite tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; (S,S)-Ir-COD-BARF Catalyst; Chiral Iridium(I) Dihydrooxazoline Phosphinite Complex; Asymmetric Iridium Hydrogenation Catalyst; Ir(S,S)-iPr-PHOX BARF Salt; (4S,5S)-Ir-PHOX-BARF; [Ir(COD)((S,S)-iPr-PHOX)]BARF
EINECS	Contact for details

Quality Control

Our high-value chiral catalysts are produced and handled under strict quality-controlled, inert environments to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis to confirm identity, enantiomeric purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to moisture and oxygen, this material must be stored under an inert atmosphere (argon or nitrogen) at temperatures between 2°C and 8°C. The container should be kept in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red crystalline or amorphous solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Enantiomeric Excess (Chiral HPLC)	≥ 99% ee
Iridium Content	~10.3% (Theoretical)
Solubility	Soluble in dichloromethane, toluene, THF; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.