Description

2H-Cyclopenta[b]furan-2-one, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(1Z,3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]hexahydro-, (3aR,4R,5R,6aS)- is a highly functionalized, stereochemically defined advanced pharmaceutical intermediate (API intermediate). Its complex structure, featuring multiple protected hydroxyl groups and a trifluoromethylphenoxy moiety, makes it a critical building block for the synthesis of novel, high-value active pharmaceutical ingredients. This compound is primarily needed by R&D laboratories and process chemistry teams in the pharmaceutical and biotechnology sectors working on complex small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, or oncology.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial manufacturing of new chemical entities (NCEs), leveraging its defined stereochemistry for high-purity yield.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new pharmacophores, especially those incorporating trifluoromethyl and silyl-protected functionalities.
• Asymmetric Synthesis: Acts as a sophisticated chiral template or scaffold for constructing other stereogenic centers in complex natural product analogs or proprietary compounds.
• Contract Manufacturing (CDMO): Supplied to Contract Development and Manufacturing Organizations for custom synthesis projects requiring high technical expertise.

Basic Information

Product Name	2H-Cyclopenta[b]furan-2-one, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(1Z,3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]hexahydro-, (3aR,4R,5R,6aS)-
CAS No.	2557327-21-4
Molecular Formula	C30H45F3O5Si2
Molecular Weight	598.85 g/mol
Synonyms	(3aR,4R,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((Z)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one; Hexahydro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(1Z,3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2H-cyclopenta[b]furan-2-one, (3aR,4R,5R,6aS)-; Advanced API Intermediate 2557327-21-4; TBDMS-protected Cyclopentafuranone Trifluoromethylphenoxy Derivative; (Z)-Isomer Silyl Ether Intermediate
EINECS	Contact for details

Quality Control

This high-purity intermediate is manufactured under strict GMP-like conditions to ensure batch-to-batch consistency for sensitive pharmaceutical synthesis. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.