Description

3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]- is a complex, high-purity synthetic organic compound designed for advanced research and development. This molecule is of significant interest for its potential as a key intermediate or active pharmaceutical ingredient (API) in targeted drug discovery programs, particularly in oncology and immunology. It is primarily intended for use by pharmaceutical R&D laboratories, biotechnology firms, and academic research institutions engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a critical building block or precursor in the synthesis of novel small-molecule drugs, particularly for targeted protein degradation (e.g., PROTACs) and kinase inhibition.
• Oncology Drug Discovery: Investigated for its potential application in developing therapies for various cancers, leveraging its complex structure designed for specific biological target engagement.
• Biochemical Tool Compound: Used in in vitro and in vivo studies to probe biological pathways and validate novel drug targets in disease models.
• Process Chemistry & Scale-Up: Acts as a reference standard or intermediate for process optimization and analytical method development during API manufacturing.
• Contract Research Organizations (CROs): Supplied to CROs conducting custom synthesis, medicinal chemistry, and preclinical testing services for client projects.

Basic Information

Product Name	3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-
CAS No.	2222112-77-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-1,3-dioxoisoindol-5-yl]piperazin-1-yl]methyl]piperidin-1-yl]pyridazine-3-carboxamide; (trans)-N-(4-(3-Chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide; PROTAC-related Intermediate; Bifunctional Degrader Compound; CAS 2222112-77-6
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing purity, related substances, and other critical parameters are available upon request. We adhere to cGMP guidelines for the manufacture of materials intended for research use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.