Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1-cyano-2-hydroxyethenyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a highly functionalized, stereochemically defined advanced pharmaceutical intermediate. This compound is valued for its complex molecular architecture, which serves as a critical building block in the synthesis of novel, high-potency active pharmaceutical ingredients (APIs). It is essential for research and development organizations and contract manufacturing organizations (CMOs) focused on innovative drug discovery, particularly in areas requiring sophisticated chiral synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex target molecules for preclinical and clinical development.
• Antiviral Drug Research: Potential building block for the development of novel nucleoside/nucleotide analogs and protease inhibitors.
• Oncology Therapeutics: Used in the research and synthesis of targeted cancer therapies and kinase inhibitors.
• Process Chemistry & Scale-Up: Serves as a critical material for route scouting, optimization, and pilot-scale production of new chemical entities (NCEs).
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct molecules with specific 3D configurations essential for biological activity.
• Contract Research & Manufacturing: Supplied to CROs and CDMOs specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1-cyano-2-hydroxyethenyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	222631-10-9
Molecular Formula	C22H34N2O6Si
Molecular Weight	450.61 g/mol
Synonyms	(3aS,4S,6R,6aR)-4-(1-Cyano-2-hydroxyvinyl)-6-[[(tert-butyldimethylsilyl)oxy]methyl]-2,2-dimethyl-tetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester; tert-Butyl (3aS,4S,6R,6aR)-4-(1-cyano-2-hydroxyvinyl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; Advanced Nucleoside Intermediate; TBDMS-protected pyrrolidine derivative.
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and purity. Our quality control protocol includes advanced analytical techniques such as HPLC, GC, NMR, and chiral analysis to verify identity, potency, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP standards for pharmaceutical applications, and custom purity grades are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.