Description

1H-Naphtho(2,3-c)pyran-3-acetic acid, 3,4,5,10-tetrahydro-4,9-dihydroxy-1-methyl-5,10-dioxo-8-(2,3,6-trideoxy-3-(dimethylamino)-β-D-arabino-hexopyranosyl)-, methyl ester, (R-(1alpha,3beta,4beta))- is a complex, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its intricate molecular architecture, featuring a naphthopyran core linked to a modified sugar moiety, makes it a valuable scaffold for the synthesis of novel bioactive compounds. This product is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focusing on new chemical entity (NCE) development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel therapeutic agents, particularly in oncology and anti-infective research.
• Research & Development (R&D): Used in academic and industrial laboratories for structure-activity relationship (SAR) studies and medicinal chemistry programs.
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in API manufacturing.
• Process Chemistry: Acts as a key intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Bioconjugation Studies: Potential use in developing targeted drug delivery systems or antibody-drug conjugates (ADCs) due to its functionalizable structure.

Basic Information

Product Name	1H-Naphtho(2,3-c)pyran-3-acetic acid, 3,4,5,10-tetrahydro-4,9-dihydroxy-1-methyl-5,10-dioxo-8-(2,3,6-trideoxy-3-(dimethylamino)-β-D-arabino-hexopyranosyl)-, methyl ester, (R-(1alpha,3beta,4beta))-
CAS No.	160523-76-2
Molecular Formula	C28H33NO11
Molecular Weight	559.56 g/mol
Synonyms	Methyl (1R,3S,4R)-3,4,5,10-tetrahydro-4,9-dihydroxy-1-methyl-5,10-dioxo-8-[(2R,3S,4S,5S,6R)-3-(dimethylamino)-2,4,5-trihydroxy-6-methyloxan-2-yl]-1H-naphtho[2,3-c]pyran-3-acetate; (1R,3S,4R)-8-[(2R,3S,4S,5S,6R)-3-(Dimethylamino)-2,4,5-trihydroxy-6-methyloxan-2-yl]-3,4,5,10-tetrahydro-4,9-dihydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid methyl ester; Aclacinomycin T methyl ester; Aclarubicin T methyl ester; Antibiotic MA 144 T1 methyl ester; NSC 354646 methyl ester
EINECS	Contact for details

Quality Control

Our 1H-Naphtho(2,3-c)pyran-3-acetic acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.