Description

5-Iodo-5-[(3aR,4R,5R,6aS)-5-(tetrahydro-2H-pyran-2-yloxy)-4-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]hexahydro-2H-cyclopenta[b]furan-2-yl]valeric acid methyl ester is a sophisticated, high-purity synthetic intermediate characterized by its complex stereochemistry and functional groups. This compound is of critical importance in advanced pharmaceutical research and development, particularly in the synthesis of prostaglandin analogs and other bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Key Intermediate in Prostaglandin Synthesis: Serves as a crucial building block for the preparation of prostaglandin E and F series analogs, which have significant therapeutic applications.
• Pharmaceutical Research & Development: Used in medicinal chemistry programs for the discovery and optimization of new drug candidates targeting inflammation, cardiovascular, and ocular diseases.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs) under cGMP conditions.
• Biochemical Tool Compound: Utilized in academic and industrial laboratories to study prostaglandin receptor biology and signaling pathways.
• Fine Chemical Synthesis: Acts as a versatile chiral synthon for the construction of other complex, biologically active natural products and their derivatives.

Basic Information

Product Name	5-Iodo-5-[(3aR,4R,5R,6aS)-5-(tetrahydro-2H-pyran-2-yloxy)-4-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]hexahydro-2H-cyclopenta[b]furan-2-yl]valeric acid methyl ester
CAS No.	102276-58-4
Molecular Formula	C30H49IO6
Molecular Weight	632.62 g/mol
Synonyms	Methyl 5-iodo-5-[(3aR,4R,5R,6aS)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-4-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]hexahydro-2H-cyclopenta[b]furan-2-yl]pentanoate; 5-Iodo-PGF2α methyl ester THP ether; Prostaglandin F2α analog intermediate; 5-Iodo-5-(4-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-yl)valeric acid methyl ester
EINECS	Contact for details

Quality Control

Our 5-Iodo-5-[(3aR,4R,5R,6aS)-5-(tetrahydro-2H-pyran-2-yloxy)-4-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]hexahydro-2H-cyclopenta[b]furan-2-yl]valeric acid methyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.