Description

2-[3-(Trifluoromethyl)Phenyl]Ethanethioamide, also known as 3-(2-Amino-2-Thioxoethyl)Benzotrifluoride, is a high-value, specialized organic intermediate featuring a benzotrifluoride core linked to a thioamide functional group. This compound matters for its role as a critical building block in the synthesis of advanced molecules, particularly in pharmaceutical and agrochemical research where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental persistence.
• Material Science Chemistry: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials.
• Ligand Synthesis: Utilized for preparing novel chelating agents and ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorinated Compound Library: An essential component for constructing diverse fluorinated compound libraries for high-throughput screening in drug discovery.

Basic Information

Item	Details
Product Name	2-[3-(Trifluoromethyl)Phenyl]Ethanethioamide / 3-(2-Amino-2-Thioxoethyl)Benzotrifluoride
CAS No.	952182-78-4
Molecular Formula	C9H8F3NS
Molecular Weight	219.23 g/mol
Synonyms	3-(2-Amino-2-thioxoethyl)benzotrifluoride; 2-[3-(Trifluoromethyl)phenyl]ethanethioamide; α-Amino-3-(trifluoromethyl)benzenepropanethioamide; 3-(Trifluoromethyl)benzylthioamide; (3-Trifluoromethylphenyl)thioacetamide; CAS 952182-78-4
EINECS	Contact for details

Quality Control

Our 2-[3-(Trifluoromethyl)Phenyl]Ethanethioamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.