Description

Ferrocene, 1-[Bis(3,5-Dimethylphenyl)Phosphino]-2-[(1S)-1-[Bis(3,5-Dimethylphenyl)Phosphino]Ethyl]-, (1R)- is a sophisticated chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to impart high enantioselectivity and catalytic efficiency in a range of transition metal-catalyzed reactions, enabling the synthesis of complex, optically pure molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing chiral intermediates in active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, allylic substitutions, and other C-C bond-forming processes to construct chiral centers with high fidelity.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of enantiomerically pure compounds used in drug discovery and development.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is often stereospecific.
• Fine Chemical and Fragrance Production: Enables the asymmetric synthesis of high-value specialty chemicals and aroma compounds.
• Academic and Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel synthetic routes in organic chemistry.

Basic Information

Product Name	Ferrocene, 1-[Bis(3,5-Dimethylphenyl)Phosphino]-2-[(1S)-1-[Bis(3,5-Dimethylphenyl)Phosphino]Ethyl]-, (1R)-
CAS No.	950982-69-1
Molecular Formula	C42H44FeP2
Molecular Weight	666.58 g/mol
Synonyms	(R)-1-[Bis(3,5-dimethylphenyl)phosphino]-2-[(S)-1-[bis(3,5-dimethylphenyl)phosphino]ethyl]ferrocene; Josiphos-type ligand derivative; Chiral ferrocenyl diphosphine; (R)-1-[(S)-2-(Bis(3,5-dimethylphenyl)phosphino)ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; 1,1'-Bis(di(3,5-dimethylphenyl)phosphino)ethylferrocene; (R,S)-PPF-P(tBu)2 derivative; (R)-[(S)-PPF-P(3,5-Me2Ph)2]; Asymmetric hydrogenation ligand 950982-69-1
EINECS	Contact for details

Quality Control

Our Ferrocene, 1-[Bis(3,5-Dimethylphenyl)Phosphino]-2-[(1S)-1-[Bis(3,5-Dimethylphenyl)Phosphino]Ethyl]-, (1R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for advanced catalytic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to moisture and oxygen, this material should be stored under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.