Description

4-((tert-Butoxycarbonylamino)Methyl)-Tetrahydro-2H-Pyran-4-Carboxylic Acid CAS NO 946761-11-1 is a high-purity, protected amino acid derivative featuring both a carboxylic acid and a Boc-protected amine functional group on a tetrahydropyran scaffold. This compound is a critical pharmaceutical intermediate and custom synthesis building block, valued for its structural rigidity and orthogonal protecting groups which enable precise, multi-step synthetic strategies. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Peptidomimetics & Constrained Peptide Design: Serves as a conformationally restricted amino acid analog to enhance metabolic stability, bioavailability, and receptor selectivity in peptide-based therapeutics.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Chemical Synthesis: Employed as a versatile building block for contract research organizations (CROs) and CDMOs for client-specific molecule construction.
• Agrochemical Research: Acts as an intermediate in developing new generation herbicides and fungicides with improved efficacy.
• Polymer & Material Science: Incorporated into specialty polymers to modify thermal and mechanical properties or to introduce functional handles for further modification.

Basic Information

Product Name	4-((tert-Butoxycarbonylamino)Methyl)-Tetrahydro-2H-Pyran-4-Carboxylic Acid
CAS No.	946761-11-1
Molecular Formula	C13H23NO5
Molecular Weight	273.32 g/mol
Synonyms	4-((Boc-amino)methyl)tetrahydro-2H-pyran-4-carboxylic acid; 4-(Boc-aminomethyl)tetrahydropyran-4-carboxylic acid; 4-(N-Boc-aminomethyl)tetrahydro-2H-pyran-4-carboxylic acid; 4-[(tert-Butoxycarbonylamino)methyl]oxane-4-carboxylic acid; Boc-Amino-THP-acid; 946761-11-1; 4-(BocNHCH2)-THP-4-COOH; 4-Carboxy-4-((tert-butoxycarbonylamino)methyl)tetrahydropyran
EINECS	Contact for details

Quality Control

Our production of 4-((tert-Butoxycarbonylamino)Methyl)-Tetrahydro-2H-Pyran-4-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and chiral analysis where applicable, to ensure compliance with research and cGMP-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and batch-to-batch consistency critical for your development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (if applicable)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.