Description

2-Propanone, 3-(1,3-Dioxolan-2-Yl)-1,1-Difluoro- is a specialized fluorinated ketone derivative, serving as a valuable building block in advanced organic synthesis. Its unique structure, featuring both a difluoroacetone moiety and a protected carbonyl group, makes it a critical intermediate for constructing complex molecules with precise functionality. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, leveraging the difluoro group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique surface properties or chemical resistance.
• Organic Synthesis Building Block: Employed in multi-step synthetic routes to introduce the difluoroacetone unit into complex molecular architectures for research purposes.
• Ligand and Catalyst Development: Utilized in the preparation of novel chelating ligands or organocatalysts for asymmetric synthesis applications.

Basic Information

Product Name	2-Propanone, 3-(1,3-Dioxolan-2-Yl)-1,1-Difluoro-
CAS No.	946078-98-4
Molecular Formula	C6H8F2O3
Molecular Weight	166.12 g/mol
Synonyms	1,1-Difluoro-3-(1,3-dioxolan-2-yl)propan-2-one; 3-(1,3-Dioxolan-2-yl)-1,1-difluoropropan-2-one; 1,1-Difluoro-3-(1,3-dioxolan-2-yl)acetone; 2-Propanone, 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-1,1-difluoro- (related); Difluoroacetone 1,3-dioxolane ketal; Fluorinated ketone dioxolane derivative
EINECS	Contact for details

Quality Control

Our 2-Propanone, 3-(1,3-Dioxolan-2-Yl)-1,1-Difluoro- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to the presence of the dioxolane protecting group and fluorinated moiety, the material should be considered moisture-sensitive and stored under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.