Description

1-Bromo-3-Chloro-5-Cyclopropylbenzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and a cyclopropyl substituent on a benzene ring, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-infective agents.
• Agrochemical Synthesis: Serves as a crucial precursor for developing new-generation herbicides, fungicides, and insecticides with the cyclopropyl moiety often contributing to biological activity.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts due to its halogen handles for further functionalization.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers where its rigid, substituted aromatic core is beneficial.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, leveraging the bromine and chlorine atoms for sequential, selective derivatization.

Basic Information

Product Name	1-Bromo-3-Chloro-5-Cyclopropylbenzene
CAS No.	945717-17-9
Molecular Formula	C9H8BrCl
Molecular Weight	231.52 g/mol
Synonyms	3-Bromo-5-Chlorocyclopropylbenzene; 5-Bromo-3-Chlorocyclopropylbenzene; 1-Bromo-3-chloro-5-cyclopropyl-benzene; (3-Bromo-5-chlorophenyl)cyclopropane; Benzene, 1-bromo-3-chloro-5-cyclopropyl-; Cyclopropyl(3-bromo-5-chlorophenyl)
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Chloro-5-Cyclopropylbenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes results from GC, HPLC, NMR, and other relevant spectroscopic methods. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.