Description

4-(4-Chlorophenylsulfonyl)-5,8-Difluoro-2H-Chromene is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonyl chromene scaffold. This compound is of significant commercial interest for its role in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily sought after by research institutions, custom synthesis organizations, and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, particularly for oncology and central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable sulfonyl and fluorinated chromene structure.
• Custom Synthesis: Serves as a specialized starting material or intermediate for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Research: Investigated as a potential intermediate for novel crop protection agents, leveraging its fluorinated aromatic system.
• Material Science Exploration: Explored for creating novel organic electronic materials or photoactive compounds due to its conjugated chromene core.

Basic Information

Product Name	4-(4-Chlorophenylsulfonyl)-5,8-Difluoro-2H-Chromene
CAS No.	944950-71-4
Molecular Formula	C15H9ClF2O3S
Molecular Weight	342.74 g/mol
Synonyms	5,8-Difluoro-4-[(4-chlorophenyl)sulfonyl]-2H-1-benzopyran; 4-(4-Chlorobenzenesulfonyl)-5,8-difluoro-2H-chromene; 5,8-Difluoro-4-(4-chlorophenylsulfonyl)chromene; 2H-1-Benzopyran, 5,8-difluoro-4-[(4-chlorophenyl)sulfonyl]-; 944950-71-4
EINECS	Contact for details

Quality Control

Our 4-(4-Chlorophenylsulfonyl)-5,8-Difluoro-2H-Chromene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.