Description

(6Ar,10As)-10A-(4-Chlorophenylsulfonyl)-1,4-Difluoro-6A,7,10,10A-Tetrahydro-6H-Benzo[C]Chromen-8(9H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating fluorine and sulfonyl functional groups. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly due to its role as a key synthetic building block. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: May be utilized in vitro to study enzyme inhibition or receptor modulation mechanisms in biological pathways.
• Custom Synthesis & Contract Manufacturing: A key material for fine chemical suppliers offering bespoke synthesis services for client-specific molecular targets.

Basic Information

Product Name	(6Ar,10As)-10A-(4-Chlorophenylsulfonyl)-1,4-Difluoro-6A,7,10,10A-Tetrahydro-6H-Benzo[C]Chromen-8(9H)-One
CAS No.	944945-07-7
Molecular Formula	C23H17ClF2O4S
Molecular Weight	462.89 g/mol
Synonyms	10A-(4-Chlorophenylsulfonyl)-1,4-difluoro-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-8(9H)-one; 1,4-Difluoro-10A-(4-chlorophenylsulfonyl)-6A,7,10,10A-tetrahydro-6H-benzochromen-8(9H)-one; Benzo[c]chromen-8(9H)-one, 10A-[(4-chlorophenyl)sulfonyl]-1,4-difluoro-6A,7,10,10A-tetrahydro-6H-; CAS 944945-07-7
EINECS	Contact for details

Quality Control

Our (6Ar,10As)-10A-(4-Chlorophenylsulfonyl)-1,4-Difluoro-6A,7,10,10A-Tetrahydro-6H-Benzo[C]Chromen-8(9H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.