Description

(αs)-2-Chloro-α-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-nitro-1H-imidazole-1-ethanol is a sophisticated, multi-functional imidazole derivative featuring a tert-butyldimethylsilyl (TBDMS) protecting group. This compound is a critical advanced pharmaceutical intermediate (API intermediate) designed for the synthesis of complex bioactive molecules, particularly in antiviral and anticancer research. It is essential for medicinal chemists and process development teams in pharmaceutical R&D and fine chemical manufacturing who require high-purity, structurally complex building blocks.

Application

• Key Intermediate in Antiviral Drug Synthesis: Serves as a protected precursor in the multi-step synthesis of novel nucleoside analogs targeting viral polymerases.
• Building Block for Anticancer Agents: Utilized in the construction of imidazole-based scaffolds for kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry & Lead Optimization: Enables structure-activity relationship (SAR) studies by providing a versatile, functionalized imidazole core for analog generation.
• Process Chemistry Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under controlled conditions.
• Protecting Group Strategy: The TBDMS moiety allows for selective protection of the hydroxymethyl group during complex multi-step organic syntheses.
• Fine Chemical & Custom Synthesis: Supplied to contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical production.

Basic Information

Item	Details
Product Name	(αs)-2-Chloro-α-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-nitro-1H-imidazole-1-ethanol
CAS No.	943610-37-5
Molecular Formula	C13H24ClN3O4Si
Molecular Weight	349.89 g/mol
Synonyms	2-Chloro-α-((tert-butyldimethylsilyloxy)methyl)-4-nitro-1H-imidazole-1-ethanol; TBDMS-protected nitroimidazole ethanol derivative; 1H-Imidazole-1-ethanol, 2-chloro-α-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-nitro-; (αS)-2-Chloro-α-(((tert-butyldimethylsilyl)oxy)methyl)-4-nitro-1H-imidazole-1-ethanol; Advanced imidazole intermediate with TBDMS group; Nitroimidazole-TBDMS ether intermediate
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality protocols suitable for pharmaceutical research. Every batch undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and MS. We provide full traceability and Certificates of Analysis (COA) detailing purity, assay, and impurity profiles upon request, ensuring compliance with internal specifications for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent decomposition. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.