Description

((2R,3S,5R)-3-Acetoxy-5-(2,4-Dioxo-5-(Phenylethynyl)-3,4-Dihydropyrimidin-1(2H)-Yl)Tetrahydrofuran-2-Yl)Methyl Acetate is a high-purity, advanced pharmaceutical intermediate with a complex nucleoside-like structure. This compound is critical for research and development in antiviral and anticancer therapeutic programs, serving as a key building block for novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and fine chemical manufacturers engaged in the synthesis of next-generation nucleoside analogs. The CAS number for this compound is 943446-57-9.

Application

This specialized intermediate is designed for high-value synthetic applications, particularly in medicinal chemistry.

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analog antiviral and anticancer drug candidates.
• Antiviral Drug Research: Used in R&D for developing therapeutics targeting viral polymerases and reverse transcriptases.
• Oncology Research: Serves as a building block for potential chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug leads.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.

Basic Information

Product Name	((2R,3S,5R)-3-Acetoxy-5-(2,4-Dioxo-5-(Phenylethynyl)-3,4-Dihydropyrimidin-1(2H)-Yl)Tetrahydrofuran-2-Yl)Methyl Acetate
CAS No.	943446-57-9
Molecular Formula	C22H20N2O7
Molecular Weight	424.41 g/mol
Synonyms	1-(5-O-Acetyl-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-5-(phenylethynyl)uracil 3',5'-Diacetate; 5-(Phenylethynyl)-1-[5-O-acetyl-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl]uracil 3',5'-Diacetate; d4T 5-(Phenylethynyl) Derivative Diacetate; Stavudine Phenylethynyl Analog Intermediate; Nucleoside Intermediate CAS 943446-57-9
EINECS	Contact for details

Quality Control

Our ((2R,3S,5R)-3-Acetoxy-5-(2,4-Dioxo-5-(Phenylethynyl)-3,4-Dihydropyrimidin-1(2H)-Yl)Tetrahydrofuran-2-Yl)Methyl Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, impurities, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.