Description

(2S,6S)-2,6-Dimethylmorpholine (R)-2-Hydroxy-2-Phenylacetate is a high-purity chiral building block and salt form of significant interest in advanced pharmaceutical synthesis. This compound is valued for its role as a key intermediate in the development of enantiomerically pure active pharmaceutical ingredients (APIs), where stereochemical control is critical for efficacy and safety. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in the development of novel therapeutics, particularly those targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug molecules, especially for neurological and psychiatric applications.
• Asymmetric Synthesis: Used as a resolving agent or a chiral auxiliary to induce stereoselectivity in chemical reactions, producing single-enantiomer compounds.
• API Salt Formation: Employed to form pharmaceutically acceptable salts of basic drug candidates, improving properties like stability, crystallinity, and bioavailability.
• Medicinal Chemistry Research: Serves as a valuable scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities in drug discovery pipelines.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for commercial pharmaceutical manufacturing under GMP guidelines.

Basic Information

Product Name	(2S,6S)-2,6-Dimethylmorpholine (R)-2-Hydroxy-2-Phenylacetate
CAS No.	943344-44-3
Molecular Formula	C14H19NO4
Molecular Weight	265.31 g/mol
Synonyms	(2S,6S)-2,6-Dimethylmorpholine (R)-Mandelate; (R)-2-Hydroxy-2-phenylacetic acid (2S,6S)-2,6-dimethylmorpholine salt; (2S,6S)-2,6-Dimethylmorpholine (R)-Mandelic acid salt; Dexmorpholine mandelate; L-Dexmorpholine D-mandelate; (S,S)-2,6-Dimethylmorpholine (R)-2-hydroxy-2-phenylacetate; (2S,6S)-Dimethylmorpholinium (R)-mandelate
EINECS	Contact for details

Quality Control

Our (2S,6S)-2,6-Dimethylmorpholine (R)-2-Hydroxy-2-Phenylacetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and GMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to relevant ICH guidelines, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.