Description

2-[(2S)-2-Amino-3-(3-Fluorophenyl)Propyl]-1H-Isoindole-1,3(2H)-Dione is a high-purity, chiral pharmaceutical intermediate featuring a fluorinated aromatic moiety and a phthalimide-protected amino group. This compound is of significant value for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, especially for CNS-targeting therapies.
• Protease Inhibitor Research: Used in the development of enzyme inhibitors where the fluorophenyl and protected amine motifs are critical for binding affinity.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog in the construction of peptide-like molecules with enhanced metabolic stability.
• Chemical Biology Probes: Utilized in the creation of labeled or tagged compounds for studying biological pathways and target engagement.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce chirality into complex molecular architectures.
• Medicinal Chemistry Optimization: Provides a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.

Basic Information

Product Name	2-[(2S)-2-Amino-3-(3-Fluorophenyl)Propyl]-1H-Isoindole-1,3(2H)-Dione
CAS No.	943325-38-0
Molecular Formula	C17H15FN2O2
Molecular Weight	298.31 g/mol
Synonyms	(2S)-2-Amino-3-(3-fluorophenyl)-1-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propane; 1H-Isoindole-1,3(2H)-dione, 2-[(2S)-2-amino-3-(3-fluorophenyl)propyl]-; (S)-2-(2-Amino-3-(3-fluorophenyl)propyl)isoindoline-1,3-dione; 3-Fluoro-D-phenylalanine N-phthalimide derivative; N-[(S)-2-Amino-3-(3-fluorophenyl)propyl]phthalimide; Fmoc-3-F-D-Phe(Phth)-OH precursor; Chiral fluorinated phthalimide protected amine
EINECS	Contact for details

Quality Control

Our 2-[(2S)-2-Amino-3-(3-Fluorophenyl)Propyl]-1H-Isoindole-1,3(2H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment and allowed to reach room temperature before opening to prevent moisture adsorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.