Description

[2-Amino-2-(3-Fluoro-Phenyl)-Ethyl]-Carbamic Acid tert-Butyl Ester is a high-purity, protected amino acid derivative serving as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring a versatile chiral intermediate with a fluorine substituent for modulating biological activity and physicochemical properties. It is primarily utilized in the pharmaceutical industry for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those targeting neurological disorders and cancer.
• Peptidomimetics Research: Used to incorporate fluorinated phenylalanine analogs into peptide backbones to enhance metabolic stability and binding affinity.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies due to the presence of the fluorine atom and protected amine functionality.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric transformations to construct complex molecules with high enantiomeric purity.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein interactions.
• Agrochemical Development: Potential intermediate in the synthesis of advanced, fluorinated crop protection agents.

Basic Information

Item	Detail
Product Name	[2-Amino-2-(3-Fluoro-Phenyl)-Ethyl]-Carbamic Acid tert-Butyl Ester
CAS No.	943325-30-2
Molecular Formula	C₁₃H₁₉FN₂O₂
Molecular Weight	254.30 g/mol
Synonyms	N-Boc-3-Fluoro-D-phenylglycinol; tert-Butyl N-[2-amino-2-(3-fluorophenyl)ethyl]carbamate; (R)-2-((tert-Butoxycarbonyl)amino)-2-(3-fluorophenyl)ethan-1-amine; (S)-2-((tert-Butoxycarbonyl)amino)-2-(3-fluorophenyl)ethan-1-amine; Boc-3-F-Phe-ol; 2-Amino-2-(3-fluorophenyl)ethyl carbamic acid tert-butyl ester; N-Boc-3-fluoro-β-phenyl-β-alaninol; 943325-30-2
EINECS	Contact for details

Quality Control

Our [2-Amino-2-(3-Fluoro-Phenyl)-Ethyl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (R- or S-isomer available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.