Description

Imidazo[1,2-B]Pyridazine, 3-[2-(Trimethylsilyl)Ethynyl]- is a high-value, functionalized heterocyclic building block used in advanced organic synthesis. This compound is critical for researchers and manufacturers developing novel pharmaceuticals and agrochemicals due to its unique molecular scaffold and reactive ethynyl handle. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, biotechnology, and agrochemical industries for constructing complex molecules and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science: Acts as a monomer or functional unit in the creation of advanced organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology: Employed as a probe or linker in bioconjugation and proteomics research due to the reactivity of the alkyne group.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne is a versatile substrate for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Product Name	Imidazo[1,2-B]Pyridazine, 3-[2-(Trimethylsilyl)Ethynyl]-
CAS No.	943320-60-3
Molecular Formula	C12H15N3Si
Molecular Weight	229.36 g/mol
Synonyms	3-[(Trimethylsilyl)ethynyl]imidazo[1,2-b]pyridazine; 3-(2-Trimethylsilylethynyl)imidazo[1,2-b]pyridazine; Imidazo[1,2-b]pyridazine, 3-[(trimethylsilyl)ethynyl]-; 3-Ethynyl-2-(trimethylsilyl)imidazo[1,2-b]pyridazine (tautomeric form); TMS-ethynyl imidazopyridazine; CAS 943320-60-3
EINECS	Contact for details

Quality Control

Every batch of Imidazo[1,2-B]Pyridazine, 3-[2-(Trimethylsilyl)Ethynyl]- is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistency for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95% (Standard Grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.