Description

(S)-Boc-5,5-Dimethyl-Pyrrolidine-2-Carboxylic Acid CAS NO 943318-67-0 is a high-purity, chiral proline derivative featuring a tert-butoxycarbonyl (Boc) protecting group and gem-dimethyl substitution at the 5-position. This compound is a critical building block in pharmaceutical research and development, valued for its role in constructing conformationally constrained peptide mimetics and bioactive molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Peptidomimetic Design: Used to introduce sterically hindered, non-natural amino acid residues into peptide backbones to enhance metabolic stability and binding affinity.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective chemical transformations.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Potential intermediate in the development of chiral active ingredients for crop protection.
• Academic Research: Employed in university and institutional labs for methodological development and novel compound library synthesis.

Basic Information

Item	Detail
Product Name	(S)-Boc-5,5-Dimethyl-Pyrrolidine-2-Carboxylic Acid
CAS No.	943318-67-0
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	(2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-5,5-dimethylpyrrolidine-2-carboxylic acid; (S)-1-Boc-5,5-dimethylproline; (S)-1-(tert-Butoxycarbonyl)-5,5-dimethylproline; (S)-5,5-Dimethyl-1-Boc-proline; (S)-N-Boc-5,5-dimethylproline; Boc-(S)-5,5-dimethylproline; tert-Butyl (2S)-5,5-dimethyl-2-carboxypyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (S)-Boc-5,5-Dimethyl-Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and optical rotation measurement, to ensure high chiral purity and chemical identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.