Description

(2,6-Xylyloxy)Acetyl Lopinavir is a key pharmaceutical intermediate, specifically a protected derivative of the potent antiretroviral drug Lopinavir. This compound is critical for ensuring the purity, stability, and controlled synthesis of the final active pharmaceutical ingredient (API). It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of HIV protease inhibitors and related antiviral therapies.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of Lopinavir API.
• Antiviral Drug Research: Used in R&D for developing novel protease inhibitors and studying structure-activity relationships (SAR).
• Process Chemistry: Employed in optimizing scalable and cost-effective manufacturing routes for Lopinavir.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in API production.
• Custom Synthesis: A starting material for the preparation of Lopinavir analogs and prodrugs for advanced therapeutic studies.

Basic Information

Product Name	(2,6-Xylyloxy)Acetyl Lopinavir
CAS No.	943250-65-5
Molecular Formula	C41H53N5O6
Molecular Weight	711.90 g/mol
Synonyms	Lopinavir (2,6-Xylyloxy)acetate; (2,6-Dimethylphenoxy)acetyl Lopinavir; Lopinavir O-(2,6-Dimethylphenyl)acetate; N-[(2S,3S,5S)-3-Hydroxy-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide; Protected Lopinavir Derivative; Lopinavir Intermediate
EINECS	Contact for details

Quality Control

Our (2,6-Xylyloxy)Acetyl Lopinavir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets the stringent requirements for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.