Description

Fmoc-4-Phosphono-Phe(Bzl)-Oh CAS NO 943148-45-6 is a protected, phosphonate-containing phenylalanine derivative, specifically engineered for advanced solid-phase peptide synthesis (SPPS). This compound is critical for introducing phosphonated tyrosine mimetics into peptide sequences, enabling the study of phosphorylation events and the development of phosphatase-resistant bioactive peptides. It is an essential building block for pharmaceutical researchers and peptide chemists in drug discovery, proteomics, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of phosphopeptide analogs and libraries.
• Phosphotyrosine Mimetic Development: Used to incorporate stable phosphonate groups that mimic phosphorylated tyrosine, crucial for studying signal transduction pathways.
• Drug Discovery & Medicinal Chemistry: Serves as a vital intermediate in the design and synthesis of peptide-based drugs targeting kinases, phosphatases, and phosphoprotein-protein interactions.
• Bioconjugation & Probe Synthesis: Facilitates the creation of labeled peptides for biochemical assays, imaging, and diagnostic applications.
• Academic & Industrial Research: Enables fundamental research in biochemistry and molecular biology focused on protein phosphorylation and dephosphorylation mechanisms.
• Custom Peptide Service Production: A high-value reagent for contract research organizations (CROs) and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-4-Phosphono-Phe(Bzl)-Oh
CAS No.	943148-45-6
Molecular Formula	C31H28NO8P
Molecular Weight	573.53 g/mol
Synonyms	Fmoc-Phe(PO(OBzl)OH)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O4-(benzylphosphono)-L-phenylalanine; Fmoc-O4-(benzylphosphono)-L-phenylalanine; Fmoc-L-Phe(PO(OBzl)OH)-OH; Fmoc-4-(Benzylphosphono)-L-phenylalanine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-(benzyloxyphosphoryl)phenyl]propanoic acid; Fmoc-Phe(PO3Bzl)-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-4-Phosphono-Phe(Bzl)-Oh is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity, meeting the exacting standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.