Description

(2S,4R)-1-(2-Aminoacetyl)-4-Benzamidopyrrolidine-2-Carboxylic Acid CAS NO 943134-39-2 is a high-purity, non-natural amino acid derivative featuring a constrained pyrrolidine scaffold. This compound serves as a critical chiral building block and intermediate in advanced pharmaceutical synthesis, enabling the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and production of peptide-based drugs, protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for metabolic and cardiovascular diseases.
• Peptidomimetic Research: Used to construct conformationally restricted peptide analogs to enhance metabolic stability and receptor selectivity.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of serine and cysteine proteases.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery campaigns.
• Academic & Contract Research: Utilized in university and CRO laboratories for fundamental research in organic synthesis and asymmetric catalysis.
• Custom Synthesis: A starting material for the custom manufacturing of specialized fine chemicals and reference standards.

Basic Information

Product Name	(2S,4R)-1-(2-Aminoacetyl)-4-Benzamidopyrrolidine-2-Carboxylic Acid
CAS No.	943134-39-2
Molecular Formula	C14H17N3O4
Molecular Weight	291.30 g/mol
Synonyms	(2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid; N-[(2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidin-2-yl]formamide derivative; (2S,4R)-4-Benzamido-1-(glycyl)pyrrolidine-2-carboxylic acid; Fmoc-D-Bpa-OH (related protected form); 4-Benzamido-D-proline derivative; Boc-D-Bpa(4-Bn)-OH (related protected form); CAS 943134-39-2
EINECS	Contact for details

Quality Control

Our (2S,4R)-1-(2-Aminoacetyl)-4-Benzamidopyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.