Description

L-Proline, 4-(Benzoylamino)-, Methyl Ester, Hydrochloride (1:1), (4R)- is a high-purity, chiral proline derivative designed for advanced synthetic applications. This compound is a critical building block in pharmaceutical research and development, offering a protected amino acid scaffold for constructing complex peptide-based molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs, enzyme inhibitors, and other bioactive molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Asymmetric Synthesis: Serves as a precursor for chiral auxiliaries, ligands, or organocatalysts in stereoselective transformations.
• Peptide Mimetics Development: Incorporated into peptidomimetic structures to enhance metabolic stability and bioavailability.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of complex APIs.
• Bioconjugation: Potential use in the synthesis of labeled compounds or antibody-drug conjugates (ADCs) due to its functionalized proline backbone.

Basic Information

Item	Details
Product Name	L-Proline, 4-(Benzoylamino)-, Methyl Ester, Hydrochloride (1:1), (4R)-
CAS No.	943134-38-1
Molecular Formula	C14H19ClN2O3
Molecular Weight	298.77 g/mol
Synonyms	(4R)-4-(Benzoylamino)-1-methyl L-prolinate hydrochloride; (4R)-4-Benzamido-L-proline methyl ester hydrochloride; Methyl (4R)-4-(benzoylamino)-L-prolinate hydrochloride; (R)-Methyl 4-benzamidopyrrolidine-2-carboxylate hydrochloride; L-Proline, 4-(benzoylamino)-, methyl ester, hydrochloride, (4R)-; 943134-38-1; 4-(Benzoylamino)-L-proline methyl ester HCl
EINECS	Contact for details

Quality Control

Our L-Proline, 4-(Benzoylamino)-, Methyl Ester, Hydrochloride (1:1), (4R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for research and development. A Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.