Description

L-Proline, n-[(1,1-Dimethylethoxy)Carbonyl]Glycyl-4-(Benzoylamino)-, (4R)- is a high-purity, stereochemically defined amino acid derivative designed for advanced research and pharmaceutical development. This compound serves as a critical chiral building block and intermediate in the synthesis of complex peptides and peptidomimetics, where precise stereochemistry is paramount. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce specific proline-based motifs with a protected amine group.
• Drug Discovery: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the construction of complex molecular libraries.
• Bioconjugation: Acts as a specialized linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Utilized in the synthesis of labeled or modified peptides for studying enzyme mechanisms and protein-protein interactions.
• Fine Chemical Synthesis: Serves as a building block for the preparation of non-natural amino acids and other sophisticated organic compounds.

Basic Information

Product Name	L-Proline, n-[(1,1-Dimethylethoxy)Carbonyl]Glycyl-4-(Benzoylamino)-, (4R)-
CAS No.	943134-34-7
Molecular Formula	C19H25N3O5
Molecular Weight	375.42 g/mol
Synonyms	Boc-Glycyl-4-(benzoylamino)-(4R)-L-proline; (4R)-1-[(2-{[(tert-Butoxy)carbonyl]amino}acetyl)-4-(benzoylamino)-L-proline; Boc-Gly-4-Bzl-(R)-Hyp-OH; N-Boc-glycyl-4-(benzamido)-(4R)-proline; tert-Butyl (2-{[(4R)-4-(benzoylamino)-2-carboxypyrrolidin-1-yl]-2-oxoethyl})carbamate; 4-(Benzoylamino)-N-[(1,1-dimethylethoxy)carbonyl]glycyl-L-proline; Boc-Gly-4-Bzl-(R)-Pro-OH (common abbreviation)
EINECS	Contact for details

Quality Control

Our L-Proline, n-[(1,1-Dimethylethoxy)Carbonyl]Glycyl-4-(Benzoylamino)-, (4R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for research and cGMP applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.