Description

2-Chloro-1-(6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl)Ethanone is a high-purity fluorinated chromanone derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. This compound is essential for pharmaceutical manufacturers and R&D laboratories focused on creating novel therapeutic agents, especially within the fields of central nervous system (CNS) and cardiovascular drug discovery.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting neurological and cardiovascular pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery programs.
• Organic Synthesis: Serves as a versatile precursor for constructing complex heterocyclic frameworks containing the chromanone and fluorine motifs.
• Agrochemical Development: Potential intermediate in the research and synthesis of new generation fluorinated agrochemicals and pesticides.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	2-Chloro-1-(6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl)Ethanone
CAS No.	943126-72-5
Molecular Formula	C11H10ClFO2
Molecular Weight	228.65 g/mol
Synonyms	2-Chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethanone; 6-Fluoro-2-(2-chloroacetyl)chroman; 2-(2-Chloroacetyl)-6-fluorochroman; 1-(6-Fluoro-3,4-dihydro-2H-chromen-2-yl)-2-chloroethanone; 2-Chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethan-1-one; 943126-72-5; Ethanone, 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-(6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl)Ethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.