Description

Thio-Miltefosine is a sulfur-containing analog of the alkylphosphocholine antineoplastic and antiprotozoal agent Miltefosine. This compound is of significant interest in pharmaceutical research and development as a key intermediate or reference standard for creating novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology and infectious disease drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel alkylphosphocholine derivatives for potential drug candidates.
• Research & Development: Used as a reference standard or a lead compound in biological screening and structure-activity relationship (SAR) studies.
• Oncology Research: Investigated for its potential antiproliferative and apoptotic effects in various cancer cell lines due to its structural similarity to active agents.
• Antiparasitic Agent Development: Explored for activity against protozoan parasites, building on the known mechanism of the parent Miltefosine compound.
• Chemical Biology: Employed as a tool compound to study lipid signaling pathways and membrane interactions in cellular systems.
• Process Chemistry: Used in scale-up and optimization studies for the manufacturing of related active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Thio-Miltefosine
CAS No.	943022-11-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Hexadecyl (2-(methylthio)ethyl) hydrogen phosphate; S-Methyl Miltefosine analog; Thioether analog of Miltefosine; Sulfur-containing Miltefosine; Alkylphosphocholine thioether; 1-Hexadecyloxy-3-[(2-(methylthio)ethyl)oxy]-2-propanol phosphoric acid ester
EINECS	Contact for details

Quality Control

Our Thio-Miltefosine is produced under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay and impurity profiles. Specifications are designed to meet the exacting requirements of pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0% Total impurities ≤ 3.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.