Description

Trityl Valsartan Sodium Salt is a key pharmaceutical intermediate, specifically a protected form of the active pharmaceutical ingredient Valsartan. This compound is of critical importance for the synthesis and research of angiotensin II receptor blockers (ARBs), a major class of cardiovascular drugs. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers engaged in the production of high-purity active pharmaceutical ingredients (APIs) and novel drug candidates.

Application

• Pharmaceutical Intermediate: Primary use in the multi-step synthesis of Valsartan API, a leading medication for hypertension and heart failure.
• Process Development & Research: Essential for route scouting, optimization, and scale-up studies in pharmaceutical process chemistry.
• Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.
• Derivatization Studies: Used in medicinal chemistry research to create novel analogs and prodrugs based on the Valsartan scaffold.
• GMP Manufacturing: Supplied as a starting material or intermediate for the production of Valsartan under Good Manufacturing Practice (GMP) guidelines.
• Academic & Contract Research: Utilized in university and CRO settings for cardiovascular drug discovery and biochemical research.

Basic Information

Product Name	Trityl Valsartan Sodium Salt
CAS No.	943019-63-4
Molecular Formula	C38H39N5NaO3
Molecular Weight	636.74 g/mol
Synonyms	N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine, Trityl Ester, Sodium Salt; Valsartan Trityl Ester Sodium Salt; (S)-N-Valeryl-N-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}valine Sodium Salt; L-Valine, N-(1-oxopentyl)-N-[[2'-(1-trityl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, sodium salt; Trityl-protected Valsartan Sodium Salt; Valsartan Trityl Ester
EINECS	Contact for details

Quality Control

Our Trityl Valsartan Sodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality is verified through comprehensive analytical testing, including HPLC for assay and purity, chiral purity determination, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each batch. We support compliance with ICH guidelines and can supply material tailored to meet specific customer requirements, including research-grade through to GMP-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.