Description

2-Amino-2-[4-(Trifluoromethoxy)Phenyl]Ethan-1-Ol is a high-value, multifunctional chiral building block featuring both an amino and a hydroxyl group on a benzylic carbon adjacent to a trifluoromethoxy-substituted aromatic ring. This unique structure makes it a critical intermediate for the synthesis of advanced pharmaceutical compounds and agrochemicals, where the trifluoromethoxy group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. It is essential for medicinal chemistry research and process development in the pharmaceutical industry, particularly for creating novel active ingredients targeting central nervous system (CNS) disorders, inflammation, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel Active Pharmaceutical Ingredients (APIs), especially in CNS drugs and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for specialty polymers with unique surface properties.
• Bioconjugation and Probe Chemistry: Utilized in the synthesis of molecular probes and bioconjugates for diagnostic and research applications.

Basic Information

Product Name	2-Amino-2-[4-(Trifluoromethoxy)Phenyl]Ethan-1-Ol
CAS No.	942996-03-4
Molecular Formula	C9H10F3NO2
Molecular Weight	221.18 g/mol
Synonyms	2-Amino-2-(4-trifluoromethoxyphenyl)ethanol; 1-(4-Trifluoromethoxyphenyl)-2-aminoethanol; 4-(Trifluoromethoxy)phenylglycinol; α-Amino-4-(trifluoromethoxy)benzenemethanol; (R/S)-2-Amino-2-[4-(trifluoromethoxy)phenyl]ethanol; 2-Amino-1-[4-(trifluoromethoxy)phenyl]ethanol; TFMP-Glycinol
EINECS	Contact for details

Quality Control

Our 2-Amino-2-[4-(Trifluoromethoxy)Phenyl]Ethan-1-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing key parameters such as assay, enantiomeric excess (where applicable), and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	Contact for details (racemic or chiral grades available)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.