Description

4H-[1,2,4]Triazolo[4,3-A][1,5]Benzodiazepine, 8-Chloro-5,6-Dihydro-9-Methoxy-4-Methyl-1-[6-(2,2,2-Trifluoroethoxy)-3-Pyridinyl]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the central nervous system (CNS) and other specialized drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the research and development of new benzodiazepine and triazolobenzodiazepine-derived drug candidates.
• Drug Discovery & Medicinal Chemistry: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in preclinical research.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex molecules for clinical trials.
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in API manufacturing.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and new synthetic methodologies.

Basic Information

Product Name	4H-[1,2,4]Triazolo[4,3-A][1,5]Benzodiazepine, 8-Chloro-5,6-Dihydro-9-Methoxy-4-Methyl-1-[6-(2,2,2-Trifluoroethoxy)-3-Pyridinyl]-
CAS No.	942928-32-7
Molecular Formula	C19H17ClF3N4O2
Molecular Weight	425.81 g/mol
Synonyms	8-Chloro-5,6-dihydro-9-methoxy-4-methyl-1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine; 942928-32-7; 8-Chloro-9-methoxy-4-methyl-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-4H,5H,6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine; Triazolobenzodiazepine derivative (8-chloro-9-methoxy-4-methyl-1-(6-(trifluoroethoxyl)pyridyl)); 1-(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)-8-chloro-5,6-dihydro-9-methoxy-4-methyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine
EINECS	Contact for details

Quality Control

Our 4H-[1,2,4]Triazolo[4,3-A][1,5]Benzodiazepine intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.