Description

tert-Butyl (S)-1-Hydroxy-3-((S)-Tetrahydro-2H-Pyran-3-Yl)Propan-2-Ylcarbamate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic utility. Its value lies in its stereochemically defined structure, which is crucial for the development of enantiomerically pure active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents, particularly in areas requiring complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Used as a precursor in stereoselective chemical reactions to construct molecules with specific three-dimensional configurations.
• Peptidomimetics Research: Serves as a constrained scaffold in the design and development of peptide-like compounds with enhanced metabolic stability.
• Medicinal Chemistry: Employed in lead optimization and structure-activity relationship (SAR) studies to improve drug potency and selectivity.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and intermediate supply.

Basic Information

Product Name	tert-Butyl (S)-1-Hydroxy-3-((S)-Tetrahydro-2H-Pyran-3-Yl)Propan-2-Ylcarbamate
CAS No.	942144-43-6
Molecular Formula	C13H25NO5
Molecular Weight	275.34 g/mol
Synonyms	(2S)-3-[(3S)-Oxan-3-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propyl alcohol; (2S)-3-[(3S)-Tetrahydropyran-3-yl]-2-[(tert-butoxycarbonyl)amino]propan-1-ol; Boc-L-threo-β-(3S-tetrahydropyran-3-yl)serinol; tert-Butoxycarbonyl-(2S,3S)-3-(tetrahydro-2H-pyran-3-yl)isoserine alcohol; tert-Butyl N-[(1S)-2-hydroxy-1-[(3S)-oxan-3-ylmethyl]ethyl]carbamate; (S)-tert-Butyl (1-hydroxy-3-((S)-tetrahydro-2H-pyran-3-yl)propan-2-yl)carbamate; BOC-Ser(Thp)-ol
EINECS	Contact for details

Quality Control

Our tert-Butyl (S)-1-Hydroxy-3-((S)-Tetrahydro-2H-Pyran-3-Yl)Propan-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.