Description

3-Oxazolidinecarboxylic Acid, 2,2-Dimethyl-4-[[(3R)-Tetrahydro-2H-Pyran-3-Yl]Methyl]-, 1,1-Dimethylethyl Ester, (4S)- is a high-purity, chiral building block of significant interest in advanced organic synthesis. Its complex, stereodefined structure makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical sectors who require reliable access to high-quality, structurally sophisticated intermediates.

Application

This chiral oxazolidine derivative serves as a versatile intermediate in several high-value chemical synthesis pathways.

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Chiral Auxiliary/Reagent: Used in asymmetric synthesis to induce stereoselectivity in the formation of new chiral centers.
• Agrochemical Synthesis: Intermediate for creating advanced, stereospecific pesticides and herbicides with improved efficacy.
• Peptidomimetics Research: Employed in the design and synthesis of peptide-like molecules for drug discovery.
• Ligand and Catalyst Development: Serves as a precursor for novel chiral ligands used in catalytic processes.
• Fine Chemical Production: Used in the multi-step synthesis of specialty chemicals and flavors & fragrances.

Basic Information

Product Name	3-Oxazolidinecarboxylic Acid, 2,2-Dimethyl-4-[[(3R)-Tetrahydro-2H-Pyran-3-Yl]Methyl]-, 1,1-Dimethylethyl Ester, (4S)-
CAS No.	942144-34-5
Molecular Formula	C16H29NO4
Molecular Weight	299.41 g/mol
Synonyms	(4S)-tert-Butyl 2,2-dimethyl-4-[[(3R)-oxan-3-yl]methyl]-1,3-oxazolidine-3-carboxylate; tert-Butyl (4S)-2,2-dimethyl-4-{[(3R)-tetrahydro-2H-pyran-3-yl]methyl}-1,3-oxazolidine-3-carboxylate; (S)-tert-Butyl 2,2-dimethyl-4-((R)-tetrahydro-2H-pyran-3-yl)methyl)oxazolidine-3-carboxylate; Oxazolidinecarboxylic acid derivative CAS 942144-34-5; Chiral Oxazolidine Ester Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all critical parameters are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.