Description

8-Chloro-6,7-Difluoro-4-Oxo-4H-Chromene-3-Carboxylic Acid Ethyl Ester is a high-purity fluorinated chromene derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its unique halogenated structure, which provides a versatile scaffold for constructing complex molecules with targeted biological or material properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in the development of fluorinated quinolone antibiotics and other bioactive heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro and chloro substituents can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialized organic materials, such as dyes, pigments, or fluorescent markers, leveraging the chromene core structure.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms or cellular processes due to its reactive ester and ketone functionalities.
• Academic & Industrial R&D: A valuable reagent for method development and exploration of new synthetic pathways in organic and medicinal chemistry laboratories.

Basic Information

Product Name	8-Chloro-6,7-Difluoro-4-Oxo-4H-Chromene-3-Carboxylic Acid Ethyl Ester
CAS No.	941867-82-9
Molecular Formula	C₁₂H₇ClF₂O₄
Molecular Weight	288.63 g/mol
Synonyms	Ethyl 8-Chloro-6,7-difluoro-4-oxo-4H-chromene-3-carboxylate; 8-Chloro-6,7-difluoro-4-oxo-4H-1-benzopyran-3-carboxylic Acid Ethyl Ester; 3-Carbethoxy-8-chloro-6,7-difluorochromone; Chromone-3-carboxylic Acid, 8-Chloro-6,7-difluoro-, Ethyl Ester; 941867-82-9; CAS 941867-82-9
EINECS	Contact for details

Quality Control

Our 8-Chloro-6,7-Difluoro-4-Oxo-4H-Chromene-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.